TY - JOUR
T1 - Gastrointestinal stromal tumors
T2 - A spectrum of disease
AU - Sturgeon, Cord
AU - Chejfec, Gregorio
AU - Espat, N. Joseph
PY - 2003/1/1
Y1 - 2003/1/1
N2 - The majority of gastrointestinal stromal tumors (GIST) express c-kit, a growth factor receptor with tyrosine kinase activity. Mutations in the c-kit proto-oncogene may lead to constitutive ligand-independent activation of c-kit and subsequent neoplastic transformation. Selective tyrosine kinase inhibitors target this property of GIST and have become the standard chemotherapy for metastatic or unresectable tumors. The mainstay of treatment, however, continues to be complete surgical resection. Tyrosine kinase inhibitors may prove expedient for adjuvant therapy, and are currently the focus of clinical trials conducted by the ACOSOG, RTOG, and ACRIN. It is important to distinguish GISTs from other mesenchymal tumors of the GI tract because of differences in natural history, as well as the efficacy of treatments targeting the GIST tyrosine kinase.
AB - The majority of gastrointestinal stromal tumors (GIST) express c-kit, a growth factor receptor with tyrosine kinase activity. Mutations in the c-kit proto-oncogene may lead to constitutive ligand-independent activation of c-kit and subsequent neoplastic transformation. Selective tyrosine kinase inhibitors target this property of GIST and have become the standard chemotherapy for metastatic or unresectable tumors. The mainstay of treatment, however, continues to be complete surgical resection. Tyrosine kinase inhibitors may prove expedient for adjuvant therapy, and are currently the focus of clinical trials conducted by the ACOSOG, RTOG, and ACRIN. It is important to distinguish GISTs from other mesenchymal tumors of the GI tract because of differences in natural history, as well as the efficacy of treatments targeting the GIST tyrosine kinase.
KW - Gastrointestinal stromal tumors (GIST)
KW - Treatment strategies
UR - http://www.scopus.com/inward/record.url?scp=0037411305&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037411305&partnerID=8YFLogxK
U2 - 10.1016/S0960-7404(02)00074-9
DO - 10.1016/S0960-7404(02)00074-9
M3 - Article
C2 - 12689667
AN - SCOPUS:0037411305
VL - 12
SP - 21
EP - 26
JO - Surgical Oncology
JF - Surgical Oncology
SN - 0960-7404
IS - 1
ER -