GATA family transcriptional factors: Emerging suspects in hematologic disorders

Juehua Gao; Yi Hua Chen; Lo Ann C. Peterson

doi:10.1186/s40164-015-0024-z

GATA family transcriptional factors: Emerging suspects in hematologic disorders

Juehua Gao^*, Yi Hua Chen, Lo Ann C. Peterson

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Review article › peer-review

52 Scopus citations

Abstract

GATA transcription factors are zinc finger DNA binding proteins that regulate transcription during development and cell differentiation. The three important GATA transcription factors GATA1, GATA2 and GATA3 play essential roles in the development and maintenance of hematopoietic systems. GATA1 is required for the erythroid and megakaryocytic commitment during hematopoiesis. GATA2 is crucial for the proliferation and survival of early hematopoietic cells, and is also involved in lineage specific transcriptional regulation as the dynamic partner of GATA1. GATA3 plays an essential role in T lymphoid cell development and immune regulation. As a result, mutations in genes encoding the GATA transcription factors or alteration in the protein expression level or their function have been linked to a variety of human hematologic disorders. In this review, we summarized the current knowledge regarding the disrupted biologic function of GATA in various hematologic disorders.

Original language	English (US)
Article number	28
Journal	Experimental Hematology and Oncology
Volume	4
Issue number	1
DOIs	https://doi.org/10.1186/s40164-015-0024-z
State	Published - Oct 6 2015

Keywords

GATA
Hematologic disorder
Transcription factor

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s40164-015-0024-z

Cite this

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title = "GATA family transcriptional factors: Emerging suspects in hematologic disorders",

abstract = "GATA transcription factors are zinc finger DNA binding proteins that regulate transcription during development and cell differentiation. The three important GATA transcription factors GATA1, GATA2 and GATA3 play essential roles in the development and maintenance of hematopoietic systems. GATA1 is required for the erythroid and megakaryocytic commitment during hematopoiesis. GATA2 is crucial for the proliferation and survival of early hematopoietic cells, and is also involved in lineage specific transcriptional regulation as the dynamic partner of GATA1. GATA3 plays an essential role in T lymphoid cell development and immune regulation. As a result, mutations in genes encoding the GATA transcription factors or alteration in the protein expression level or their function have been linked to a variety of human hematologic disorders. In this review, we summarized the current knowledge regarding the disrupted biologic function of GATA in various hematologic disorders.",

keywords = "GATA, Hematologic disorder, Transcription factor",

author = "Juehua Gao and Chen, {Yi Hua} and Peterson, {Lo Ann C.}",

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doi = "10.1186/s40164-015-0024-z",

language = "English (US)",

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T1 - GATA family transcriptional factors

T2 - Emerging suspects in hematologic disorders

AU - Gao, Juehua

AU - Chen, Yi Hua

AU - Peterson, Lo Ann C.

PY - 2015/10/6

Y1 - 2015/10/6

N2 - GATA transcription factors are zinc finger DNA binding proteins that regulate transcription during development and cell differentiation. The three important GATA transcription factors GATA1, GATA2 and GATA3 play essential roles in the development and maintenance of hematopoietic systems. GATA1 is required for the erythroid and megakaryocytic commitment during hematopoiesis. GATA2 is crucial for the proliferation and survival of early hematopoietic cells, and is also involved in lineage specific transcriptional regulation as the dynamic partner of GATA1. GATA3 plays an essential role in T lymphoid cell development and immune regulation. As a result, mutations in genes encoding the GATA transcription factors or alteration in the protein expression level or their function have been linked to a variety of human hematologic disorders. In this review, we summarized the current knowledge regarding the disrupted biologic function of GATA in various hematologic disorders.

AB - GATA transcription factors are zinc finger DNA binding proteins that regulate transcription during development and cell differentiation. The three important GATA transcription factors GATA1, GATA2 and GATA3 play essential roles in the development and maintenance of hematopoietic systems. GATA1 is required for the erythroid and megakaryocytic commitment during hematopoiesis. GATA2 is crucial for the proliferation and survival of early hematopoietic cells, and is also involved in lineage specific transcriptional regulation as the dynamic partner of GATA1. GATA3 plays an essential role in T lymphoid cell development and immune regulation. As a result, mutations in genes encoding the GATA transcription factors or alteration in the protein expression level or their function have been linked to a variety of human hematologic disorders. In this review, we summarized the current knowledge regarding the disrupted biologic function of GATA in various hematologic disorders.

KW - GATA

KW - Hematologic disorder

KW - Transcription factor

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GATA family transcriptional factors: Emerging suspects in hematologic disorders

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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