GATA family transcriptional factors: Emerging suspects in hematologic disorders

Juehua Gao*, Yi Hua Chen, Lo Ann C. Peterson

*Corresponding author for this work

Research output: Contribution to journalReview article

27 Scopus citations

Abstract

GATA transcription factors are zinc finger DNA binding proteins that regulate transcription during development and cell differentiation. The three important GATA transcription factors GATA1, GATA2 and GATA3 play essential roles in the development and maintenance of hematopoietic systems. GATA1 is required for the erythroid and megakaryocytic commitment during hematopoiesis. GATA2 is crucial for the proliferation and survival of early hematopoietic cells, and is also involved in lineage specific transcriptional regulation as the dynamic partner of GATA1. GATA3 plays an essential role in T lymphoid cell development and immune regulation. As a result, mutations in genes encoding the GATA transcription factors or alteration in the protein expression level or their function have been linked to a variety of human hematologic disorders. In this review, we summarized the current knowledge regarding the disrupted biologic function of GATA in various hematologic disorders.

Original languageEnglish (US)
Article number28
JournalExperimental Hematology and Oncology
Volume4
Issue number1
DOIs
StatePublished - Oct 6 2015

Keywords

  • GATA
  • Hematologic disorder
  • Transcription factor

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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