GATA1s goes germline

Gina Mundschau*, John Crispino

*Corresponding author for this work

Research output: Contribution to journalShort survey

6 Scopus citations


Acquired somatic mutations in the transcription factor GATA1 are a defining feature of acute megakaryocytic leukemia in children with Down syndrome. A new study shows that similar inherited GATA1 mutations do not promote leukemia in the absence of trisomy 21 but lead to defects in multiple hematopoietic lineages.

Original languageEnglish (US)
Pages (from-to)741-742
Number of pages2
JournalNature Genetics
Issue number7
StatePublished - Jul 1 2006


ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

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