GATA1s goes germline

Gina Mundschau; John Crispino

doi:10.1038/ng0706-741

GATA1s goes germline

Gina Mundschau^*, John Crispino

^*Corresponding author for this work

Medicine, Hematology Oncology Division

Research output: Contribution to journal › Short survey › peer-review

6 Scopus citations

Abstract

Acquired somatic mutations in the transcription factor GATA1 are a defining feature of acute megakaryocytic leukemia in children with Down syndrome. A new study shows that similar inherited GATA1 mutations do not promote leukemia in the absence of trisomy 21 but lead to defects in multiple hematopoietic lineages.

Original language	English (US)
Pages (from-to)	741-742
Number of pages	2
Journal	Nature Genetics
Volume	38
Issue number	7
DOIs	https://doi.org/10.1038/ng0706-741
State	Published - Jul 2006

ASJC Scopus subject areas

Genetics

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title = "GATA1s goes germline",

abstract = "Acquired somatic mutations in the transcription factor GATA1 are a defining feature of acute megakaryocytic leukemia in children with Down syndrome. A new study shows that similar inherited GATA1 mutations do not promote leukemia in the absence of trisomy 21 but lead to defects in multiple hematopoietic lineages.",

author = "Gina Mundschau and John Crispino",

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AU - Crispino, John

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AB - Acquired somatic mutations in the transcription factor GATA1 are a defining feature of acute megakaryocytic leukemia in children with Down syndrome. A new study shows that similar inherited GATA1 mutations do not promote leukemia in the absence of trisomy 21 but lead to defects in multiple hematopoietic lineages.

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JO - Nature Genetics

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GATA1s goes germline

Abstract

ASJC Scopus subject areas

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