GATOR2 rings GATOR1 to speak to mTORC1

Umakant Sahu, Issam Ben-Sahra*

*Corresponding author for this work

Research output: Contribution to journalComment/debatepeer-review

1 Scopus citations

Abstract

The mechanistic target of rapamycin complex 1 (mTORC1) senses cellular leucine levels through the GATOR1/2-Rag axis. Jiang et al. show that the Ring domains of GATOR2 subunits maintain the integrity of the complex and promote ubiquitination and inhibition of GATOR1, thereby leading to mTORC1 activation.

Original languageEnglish (US)
Pages (from-to)6-8
Number of pages3
JournalMolecular cell
Volume83
Issue number1
DOIs
StatePublished - Jan 5 2023

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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