Abstract
The mechanistic target of rapamycin complex 1 (mTORC1) senses cellular leucine levels through the GATOR1/2-Rag axis. Jiang et al. show that the Ring domains of GATOR2 subunits maintain the integrity of the complex and promote ubiquitination and inhibition of GATOR1, thereby leading to mTORC1 activation.
Original language | English (US) |
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Pages (from-to) | 6-8 |
Number of pages | 3 |
Journal | Molecular cell |
Volume | 83 |
Issue number | 1 |
DOIs |
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State | Published - Jan 5 2023 |
Funding
This work is supported by grants from the National Institutes of Health , United States ( R01GM143334 to I.B.-S.).
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology