GATOR2 rings GATOR1 to speak to mTORC1

Umakant Sahu; Issam Ben-Sahra

doi:10.1016/j.molcel.2022.12.011

GATOR2 rings GATOR1 to speak to mTORC1

Umakant Sahu, Issam Ben-Sahra^*

^*Corresponding author for this work

Biochemistry and Molecular Genetics

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

The mechanistic target of rapamycin complex 1 (mTORC1) senses cellular leucine levels through the GATOR1/2-Rag axis. Jiang et al. show that the Ring domains of GATOR2 subunits maintain the integrity of the complex and promote ubiquitination and inhibition of GATOR1, thereby leading to mTORC1 activation.

Original language	English (US)
Pages (from-to)	6-8
Number of pages	3
Journal	Molecular cell
Volume	83
Issue number	1
DOIs	https://doi.org/10.1016/j.molcel.2022.12.011
State	Published - Jan 5 2023

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1016/j.molcel.2022.12.011

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title = "GATOR2 rings GATOR1 to speak to mTORC1",

abstract = "The mechanistic target of rapamycin complex 1 (mTORC1) senses cellular leucine levels through the GATOR1/2-Rag axis. Jiang et al. show that the Ring domains of GATOR2 subunits maintain the integrity of the complex and promote ubiquitination and inhibition of GATOR1, thereby leading to mTORC1 activation.",

author = "Umakant Sahu and Issam Ben-Sahra",

note = "Funding Information: This work is supported by grants from the National Institutes of Health , United States ( R01GM143334 to I.B.-S.). Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",

year = "2023",

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doi = "10.1016/j.molcel.2022.12.011",

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AB - The mechanistic target of rapamycin complex 1 (mTORC1) senses cellular leucine levels through the GATOR1/2-Rag axis. Jiang et al. show that the Ring domains of GATOR2 subunits maintain the integrity of the complex and promote ubiquitination and inhibition of GATOR1, thereby leading to mTORC1 activation.

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GATOR2 rings GATOR1 to speak to mTORC1

Abstract

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