Gaussian random fields on sub-manifolds for characterizing brain surfaces*

Sarang C. Joshi, Ayananshu Banerjee, Gary E. Christensen, John G. Csernansky, John W. Hailer, Michael I. Miller, Lei Wang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

11 Scopus citations


This paper provides analytical methods for characterizing the variation of the shape of neuroanatomically significant substructures of the brain in an ensemble of brain images. The focus of this paper is on the neuro-anatomical variation of the “shape” of 2-dimensional surfaces in the brain. Brain surfaces are studied by building templates that are smooth sub-manifolds of the underlying coordinate system of the brain. Variation of the shape in populations is quantified via defining Gaassian random vector fields on these sub-manifolds. Methods for the empirical construction of Ganssian random vector fields for representing the variations of the substructures are presented. As an example, using these methods we characterize the shape of the hippocampus in a population of normal controls and schizophrenic brains. Results from a recently completed study comparing shapes of the hippocampus in a group of matched schizophrenic and normal control subjects are presented. Bayesian hypothesis test is formulated to cluster the normal and schizophrenic hippocampi in the population of 20 individuals.

Original languageEnglish (US)
Title of host publicationInformation Processing in Medical Imaging - 15th International Conference, IPMI 1997, Proceedings
EditorsJames Duncan, Gene Gindi
PublisherSpringer Verlag
Number of pages6
ISBN (Print)3540630465, 9783540630463
StatePublished - 1997
Event15th International Conference on Information Processing in Medical Imaging, IPMI 1997 - Poultney, United States
Duration: Jun 9 1997Jun 13 1997

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349


Other15th International Conference on Information Processing in Medical Imaging, IPMI 1997
CountryUnited States

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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