GCN2-dependent metabolic stress is essential for endotoxemic cytokine induction and pathology

INIS

• macrophages 100%
• lipopolysaccharides 100%
• inflammation 80%
• amino acids 80%
• mice 60%
• knock-out reactions 60%
• cytokines 60%
• proteins 40%
• production 40%
• stimulation 40%
• mortality 40%
• signals 40%
• reduction 40%
• interleukins 40%
• tryptophan 40%
• data 20%
• animals 20%
• in vivo 20%
• in vitro 20%
• supply 20%
• environment 20%
• pathology 20%
• sensitivity 20%
• genes 20%
• receptors 20%
• kinases 20%
• induction 20%
• ligands 20%
• lethal doses 20%
• septicemia 20%

Immunology and Microbiology

• Macrophage 100%
• Stress 80%
• Knockout Mouse 40%
• Interleukin 6 40%
• Mortality 40%
• Reduction (Chemistry) 40%
• Immune Response 20%
• TLR4 20%
• Gene Expression 20%
• Mouse Model 20%
• Cytokine Production 20%
• Lineages 20%
• Growth Arrest and DNA Damage Inducible Protein 153 20%
• Activating Transcription Factor 4 20%
• Indoleamine 2,3-dioxygenase 20%
• Animal 20%
• Inflammation 20%