Gd(III)-nanodiamond conjugates for MRI contrast enhancement

Lisa M. Manus; Daniel J. Mastarone; Emily A. Waters; Xue Qing Zhang; Elise A. Schultz-Sikma; Keith W. MacRenaris; Dean Ho; Thomas J. Meade

doi:10.1021/nl903264h

Gd(III)-nanodiamond conjugates for MRI contrast enhancement

Lisa M. Manus, Daniel J. Mastarone, Emily A. Waters, Xue Qing Zhang, Elise A. Schultz-Sikma, Keith W. MacRenaris, Dean Ho, Thomas J. Meade

Research output: Contribution to journal › Article › peer-review

240 Scopus citations

Abstract

A Gd(III)-nanodiamond conjugate [Gd(III)-ND] was prepared and characterized, enabling detection of nanodiamonds by MR imaging. The Gd(III)-ND particles significantly reduced the T₁ of water protons with a per-Gd(III) relaxlvity of 58.82 ± 1.18 mM^-1 s^-1 at 1.5 T (60 MHz). This represents a 10-fold increase compared to the monomer Gd(III) complex (r₁= 5.42 ± 0.20 mM^-1 s ^-1) and is among the highest per-Gd(III) relaxivities reported.

Original language	English (US)
Pages (from-to)	484-489
Number of pages	6
Journal	Nano letters
Volume	10
Issue number	2
DOIs	https://doi.org/10.1021/nl903264h
State	Published - Feb 10 2010

Keywords

Gadolinium
MR contrast agents
Nanodiamonds
Nanomedicine

ASJC Scopus subject areas

Bioengineering
Chemistry(all)
Materials Science(all)
Condensed Matter Physics
Mechanical Engineering

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10.1021/nl903264h

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title = "Gd(III)-nanodiamond conjugates for MRI contrast enhancement",

abstract = "A Gd(III)-nanodiamond conjugate [Gd(III)-ND] was prepared and characterized, enabling detection of nanodiamonds by MR imaging. The Gd(III)-ND particles significantly reduced the T1 of water protons with a per-Gd(III) relaxlvity of 58.82 ± 1.18 mM-1 s-1 at 1.5 T (60 MHz). This represents a 10-fold increase compared to the monomer Gd(III) complex (r1= 5.42 ± 0.20 mM-1 s -1) and is among the highest per-Gd(III) relaxivities reported.",

keywords = "Gadolinium, MR contrast agents, Nanodiamonds, Nanomedicine",

author = "Manus, {Lisa M.} and Mastarone, {Daniel J.} and Waters, {Emily A.} and Zhang, {Xue Qing} and Schultz-Sikma, {Elise A.} and MacRenaris, {Keith W.} and Dean Ho and Meade, {Thomas J.}",

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T1 - Gd(III)-nanodiamond conjugates for MRI contrast enhancement

AU - Manus, Lisa M.

AU - Mastarone, Daniel J.

AU - Waters, Emily A.

AU - Zhang, Xue Qing

AU - Schultz-Sikma, Elise A.

AU - MacRenaris, Keith W.

AU - Ho, Dean

AU - Meade, Thomas J.

PY - 2010/2/10

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N2 - A Gd(III)-nanodiamond conjugate [Gd(III)-ND] was prepared and characterized, enabling detection of nanodiamonds by MR imaging. The Gd(III)-ND particles significantly reduced the T1 of water protons with a per-Gd(III) relaxlvity of 58.82 ± 1.18 mM-1 s-1 at 1.5 T (60 MHz). This represents a 10-fold increase compared to the monomer Gd(III) complex (r1= 5.42 ± 0.20 mM-1 s -1) and is among the highest per-Gd(III) relaxivities reported.

AB - A Gd(III)-nanodiamond conjugate [Gd(III)-ND] was prepared and characterized, enabling detection of nanodiamonds by MR imaging. The Gd(III)-ND particles significantly reduced the T1 of water protons with a per-Gd(III) relaxlvity of 58.82 ± 1.18 mM-1 s-1 at 1.5 T (60 MHz). This represents a 10-fold increase compared to the monomer Gd(III) complex (r1= 5.42 ± 0.20 mM-1 s -1) and is among the highest per-Gd(III) relaxivities reported.

KW - Gadolinium

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