Gd(III)-nanodiamond conjugates for MRI contrast enhancement

Lisa M. Manus, Daniel J. Mastarone, Emily A. Waters, Xue Qing Zhang, Elise A. Schultz-Sikma, Keith W. MacRenaris, Dean Ho, Thomas J. Meade

Research output: Contribution to journalArticlepeer-review

263 Scopus citations


A Gd(III)-nanodiamond conjugate [Gd(III)-ND] was prepared and characterized, enabling detection of nanodiamonds by MR imaging. The Gd(III)-ND particles significantly reduced the T1 of water protons with a per-Gd(III) relaxlvity of 58.82 ± 1.18 mM-1 s-1 at 1.5 T (60 MHz). This represents a 10-fold increase compared to the monomer Gd(III) complex (r1= 5.42 ± 0.20 mM-1 s -1) and is among the highest per-Gd(III) relaxivities reported.

Original languageEnglish (US)
Pages (from-to)484-489
Number of pages6
JournalNano letters
Issue number2
StatePublished - Feb 10 2010


  • Gadolinium
  • MR contrast agents
  • Nanodiamonds
  • Nanomedicine

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering


Dive into the research topics of 'Gd(III)-nanodiamond conjugates for MRI contrast enhancement'. Together they form a unique fingerprint.

Cite this