Gd(III)-nanodiamond conjugates for MRI contrast enhancement

Lisa M. Manus, Daniel J. Mastarone, Emily A. Waters, Xue Qing Zhang, Elise A. Schultz-Sikma, Keith W. MacRenaris, Dean Ho, Thomas J. Meade

Research output: Contribution to journalArticlepeer-review

240 Scopus citations

Abstract

A Gd(III)-nanodiamond conjugate [Gd(III)-ND] was prepared and characterized, enabling detection of nanodiamonds by MR imaging. The Gd(III)-ND particles significantly reduced the T1 of water protons with a per-Gd(III) relaxlvity of 58.82 ± 1.18 mM-1 s-1 at 1.5 T (60 MHz). This represents a 10-fold increase compared to the monomer Gd(III) complex (r1= 5.42 ± 0.20 mM-1 s -1) and is among the highest per-Gd(III) relaxivities reported.

Original languageEnglish (US)
Pages (from-to)484-489
Number of pages6
JournalNano letters
Volume10
Issue number2
DOIs
StatePublished - Feb 10 2010

Keywords

  • Gadolinium
  • MR contrast agents
  • Nanodiamonds
  • Nanomedicine

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

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