Gelfoam and autologous clot embolization: Effect on coagulation

Jack E. Ansell*, Warren C. Widrich, Willard C. Johnson, Max Maizels, Alan H. Robbins, Donald C. Nabseth, Daniel Deykin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

An episode of disseminated intravascular coagulation following therapeutic gelfoam embolization to control bleeding from esophageal varices in a patient with liver disease is presented. We have since followed 13 patients prospectively (six control and seven gelfoam/autologous clot) to determine the effect of this procedure on clotting. We were unable to show significant differences between the two groups as measured by the prothrombin time, activated partial thromboplastin time, thrombin time, fibrinogen and platelet count. However, fibrin (ogen) degradation products were significantly elevated (p <.01) in the gelfoam/autologous clot group. We suspect this occurred secondary to clot lysis at the site of embolization. No subsequent bleeding diathesis attributable to this abnormality occurred in any of the patients.

Original languageEnglish (US)
Pages (from-to)115-120
Number of pages6
JournalInvestigative radiology
Volume13
Issue number2
DOIs
StatePublished - Jan 1 1978

Keywords

  • Autologous clot
  • Gelfoam
  • Intravascular coagulation
  • Therapeutic embolization

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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