Abstract
It remains unclear how to optimally incorporate gemcitabine and docetaxel into the management of patients with recurrent osteosarcoma. We describe 4 pediatric patients with recurrent osteosarcoma who were treated with gemcitabine±docetaxel and resection. One patient had a partial response and 2 had stable disease. Two patients subsequently underwent surgical resections. Median duration of response was 8 months and was longer for patients who underwent resection. One patient remains disease-free 57 months from recurrence. Our limited series provides additional support for the use of gemcitabine±docetaxel for recurrent osteosarcoma and suggests benefit of concurrent local control measures if possible.
Original language | English (US) |
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Journal | Journal of Pediatric Hematology/Oncology |
Volume | 34 |
Issue number | 2 |
DOIs | |
State | Published - Mar 1 2012 |
Keywords
- gemcitabine
- osteosarcoma
- pediatric
- recurrent
- refractory
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Oncology
- Hematology