Gemcitabine/nab-paclitaxel as second-line therapy following FOLFIRINOX in metastatic/advanced pancreatic cancer- retrospective analysis of response

Khanh T. Nguyen, Aparna Kalyan, H. Scott Beasley, Aatur D. Singhi, Weijing Sun, Herbert J. Zeh, Daniel Normolle, Nathan Bahary*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Background: Given the tolerability of nPG in first-line therapy, we desired to evaluate the response and toxicity profiles of second-line gemcitabine with nab-paclitaxel (nPG) following FOLFIRINOX. Methods: We retrospectively identified 30 patients who received first-line FOLFIRINOX for unresectable or metastatic pancreatic adenocarcinoma followed by second-line nPG. Response was evaluated by RECIST criteria and carbohydrate antigen 19-9 (CA19-9) change. Results: Median age was 63 years with 77% percent having metastatic disease. Nineteen patients (63%) achieved PR based on CA19-9. Median overall survival (OS) with nPG was 12.4 months (mo) and median progression-free survival (PFS) was 3.8 mo. Median PFS and OS for patients with at least stable CA19-9 were 4.7 and 14 mo since initiation of nPG. Patients with an increased CA19-9 level during nPG had a shorter median PFS (1.4 mo) and OS (5.4 mo). A significant PFS difference was demonstrated in patients with at least stable disease as the best RECIST response versus in those with progressive disease (5.5 vs. 1.9 mo, P < 0.001). Grade 3/4 adverse events include thrombocytopenia (33%), anemia (23%), nausea (17%), lymphopenia (7%), infectious complications (6%), diarrhea (3%), and neuropathy (3%). Conclusions: This study demonstrates a clinical benefit of second-line nPG. The study also suggests a possible use of CA19-9 to predict response to therapy

Original languageEnglish (US)
Pages (from-to)556-565
Number of pages10
JournalJournal of Gastrointestinal Oncology
Volume8
Issue number3
DOIs
StatePublished - Jun 1 2017

Keywords

  • Carbohydrate antigen 19-9 (CA19-9)
  • FOLFIRINOX
  • Gemcitabine
  • Nab-paclitaxel
  • Pancreatic cancer

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology

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