Gender differences in cholesterol-lowering medication prescribing in peripheral artery disease

Mary M. McDermott*, Philip Greenland, George Reed, Kathleen M. Mazor, Philip A. Merriam, Rex Graff, Huimin Tao, Sherry Pagoto, Larry Manheim, Melina R. Kibbe, Ira S. Ockene

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Among 320 patients with lower extremity peripheral artery disease (PAD) and low-density lipoprotein-cholesterol (LDL-C) levels > 70 mg/dl, we determined whether male sex, higher education, and greater self-efficacy for willingness to request therapy from one's physician were associated with increases in LDL-C-lowering medication and achievement of an LDL-C level < 70 mg/dl at 1-year follow-up. Participants were enrolled in a randomized controlled clinical trial to determine whether a telephone counseling intervention can help PAD patients achieve an LDL-C level < 70 mg/dl, compared to usual care and attention control conditions, respectively. Adjusting for age, race, comorbidities, PAD severity, and other covariates, male sex (odds ratio = 3.33, 95% confidence interval = 1.64 to 6.77, p = 0.001) was associated with a higher likelihood of adding cholesterol-lowering medication during follow-up, but was not associated with achieving an LDL-C < 70 mg/dl (odds ratio = 1.09, 95% confidence interval = 0.55 to 2.18). No associations of education level or self-efficacy with study outcomes were identified. In conclusion, male PAD patients with baseline LDL-C levels ≥ 70 mg/dl were more likely to intensify LDL-C-lowering medication during 1-year follow-up than female PAD patients. Despite greater increases in LDL-C-lowering medication among female PAD patients, there was no difference in the degree of LDL-C lowering during the study between men and women with PAD. Clinical Trial Registration-URL:

Original languageEnglish (US)
Pages (from-to)428-435
Number of pages8
JournalVascular Medicine
Issue number6
StatePublished - Dec 2011


  • intermittent claudication
  • peripheral artery disease
  • prevention
  • quality of care

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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