Gender is a determinative factor in the initial clinical presentation of eosinophilic esophagitis

K. L. Lynch, S. Dhalla, V. Chedid, W. J. Ravich, E. M. Stein, E. A. Montgomery, Bruce Scott Bochner, J. O. Clarke

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Eosinophilic esophagitis (EoE) is a chronic, immune-mediated disease resulting in symptoms of esophageal dysmotility. Abnormalities include dysphagia, food impaction and reflux. Although men appear to comprise a majority of the EoE population, few studies have directly assessed gender-associated clinical differences. The aim of this study is to identify the effect of gender on the initial clinical presentation of adult-onset EoE patients. We reviewed our electronic medical record database from January 2008 to December 2011 for adults diagnosed with EoE per the 2011 updated consensus guidelines. Patient demographics, presenting symptoms, endoscopy findings and complications were recorded. Proportions were compared using chi-squared analysis, and means were compared using the Student's t-test. A total of 162 patients met the inclusion criteria and 71 (44%) were women. Women were more likely to report chest pain (P = 0.03) and heartburn (P = 0.06), whereas men more commonly reported dysphagia (P = 0.04) and a history of food impaction (P = 0.05). Endoscopic findings were similar between groups. No patients suffered esophageal perforations. These data suggest that men report more fibrostenotic symptoms and women report more inflammatory symptoms at the time of diagnosis. There was no difference in endoscopic findings between genders. This is one of the only reviews comparing differences in clinical presentation, endoscopic findings and complications between gender for EoE. The current recommended guidelines state that any patient with symptoms of esophageal dysfunction should be biopsied for EoE. Our findings support biopsying patients with typical and atypical symptoms of dysmotility including heartburn and chest pain.

Original languageEnglish (US)
Pages (from-to)174-178
Number of pages5
JournalDiseases of the Esophagus
Volume29
Issue number2
DOIs
StatePublished - Feb 1 2016

Fingerprint

Eosinophilic Esophagitis
Heartburn
Deglutition Disorders
Chest Pain
Esophageal Motility Disorders
Guidelines
Esophageal Perforation
Food
Electronic Health Records
Immune System Diseases
Endoscopy
Consensus
Demography
Databases
Students
Population

Keywords

  • Dysphagia
  • Eosinophilic esophagitis
  • Food impaction

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Lynch, K. L., Dhalla, S., Chedid, V., Ravich, W. J., Stein, E. M., Montgomery, E. A., ... Clarke, J. O. (2016). Gender is a determinative factor in the initial clinical presentation of eosinophilic esophagitis. Diseases of the Esophagus, 29(2), 174-178. https://doi.org/10.1111/dote.12307
Lynch, K. L. ; Dhalla, S. ; Chedid, V. ; Ravich, W. J. ; Stein, E. M. ; Montgomery, E. A. ; Bochner, Bruce Scott ; Clarke, J. O. / Gender is a determinative factor in the initial clinical presentation of eosinophilic esophagitis. In: Diseases of the Esophagus. 2016 ; Vol. 29, No. 2. pp. 174-178.
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Lynch, KL, Dhalla, S, Chedid, V, Ravich, WJ, Stein, EM, Montgomery, EA, Bochner, BS & Clarke, JO 2016, 'Gender is a determinative factor in the initial clinical presentation of eosinophilic esophagitis' Diseases of the Esophagus, vol. 29, no. 2, pp. 174-178. https://doi.org/10.1111/dote.12307

Gender is a determinative factor in the initial clinical presentation of eosinophilic esophagitis. / Lynch, K. L.; Dhalla, S.; Chedid, V.; Ravich, W. J.; Stein, E. M.; Montgomery, E. A.; Bochner, Bruce Scott; Clarke, J. O.

In: Diseases of the Esophagus, Vol. 29, No. 2, 01.02.2016, p. 174-178.

Research output: Contribution to journalArticle

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AU - Stein, E. M.

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AU - Clarke, J. O.

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