Gender related differences in cerebral autoregulation in older healthy subjects

Brian M. Deegan, Farzaneh A. Sorond, Lewis A. Lipsitz, Gearóid Ólaighin, Jorge M. Serrador

Research output: Chapter in Book/Report/Conference proceedingConference contribution

28 Scopus citations

Abstract

Cerebral autoregulation is an intrinsic mechanism of the cerebrovasculature that maintains cerebral blood flow relatively constant over a wide range of blood pressures. Recent studies have shown sex differences in cerebral autoregulation in adolescents and young adults. We evaluated cerebral auturegulation in 419 (186 male) subjects over the age of 70 recruited as part of the MOBILIZE Boston study. CO2 reactivity, transfer function gain and autoregulatory index (ARI) during sit to stand tests were assessed. Female subjects had significantly higher CO2 reactivity (p < 0.001) and vasomotor range (p<0.001) as well as ARI indices (p<0.001) and lower transfer function gain in the autoregulatory band (p=0.001), implying better cerebral autoregulation, than male subjects. The mechanisms of sex based differences in cerebral autoregulation remain unclear, but the results of this study highlight the need for future work to better understand these underlying autoregulatory differences.

Original languageEnglish (US)
Title of host publicationProceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Subtitle of host publicationEngineering the Future of Biomedicine, EMBC 2009
PublisherIEEE Computer Society
Pages2859-2862
Number of pages4
ISBN (Print)9781424432967
DOIs
StatePublished - 2009
Event31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN, United States
Duration: Sep 2 2009Sep 6 2009

Publication series

NameProceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009

Other

Other31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
CountryUnited States
CityMinneapolis, MN
Period9/2/099/6/09

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Biomedical Engineering
  • Medicine(all)

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