Gender-specific differences in expression in human lymphoblastoid cell lines

Wei Zhang, Wasim K. Bleibel, Cheryl A. Roe, Nancy J. Cox, M. Eileen Dolan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Women and men have different risks for certain diseases and they often respond differently to treatment. These differences could be due to the sex-specific differences in the expression of genes related to primary disease susceptibility or pharmacodynamic targets. To evaluate the sex-specific pattern of gene expression, we compared gene expression levels using a publicly available microarray dataset of 233 (115 women and 118 men) lymphoblastoid cell lines. From the 4799 probes meeting a specified minimal level of expression, 10 genes (P<0.005, permutation adjusted false discovery rate less than 50%) located on autosomal chromosomes were identified using a permutation-based approach. These genes were found to be over-represented in certain gene ontology terms of biological process (cell adhesion, apoptosis, transcription and signal transduction), and molecular function (structural molecule activity, zinc ion binding, transcription factor activity and protein binding). A Kyoto Encyclopedia of Genes and Genomes pathway analysis indicated that two known pathways are over-represented: adherens junction and cytokine-cytokine receptor interaction.

Original languageEnglish (US)
Pages (from-to)447-450
Number of pages4
JournalPharmacogenetics and genomics
Volume17
Issue number6
DOIs
StatePublished - Jun 2007

Keywords

  • Centre d' Etude du Polymorphisme Humain
  • Gene expression
  • Lymphoblastoid cell lines
  • Sex difference

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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