Gene expression changes in blood as a putative biomarker for Huntington's disease

Luca Lovrecic, Andrej Kastrin, Jan Kobal, Zvezdan Pirtosek, Dimitri Krainc, Borut Peterlin*

*Corresponding author for this work

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Several studies demonstrated alterations of gene expression in blood in various neurological disorders including Huntington's disease (HD). Using microarray technology, a recent study identified a large number of significantly altered mRNAs in HD blood, from which a 12-gene set was selected as classifier for discriminating controls and HD patients. The aim of our study was to validate expression changes of these 12 genes in an independent cohort of HD patients and evaluate their sensitivity and specificity. Four different subject groups were included-patients with HD, Parkinson's disease (PD), acute ischemic stroke (AS) and healthy controls. Although the previous results were successfully validated, gene expression changes in HD blood partly overlapped with those observed in blood from PD and AS patients. Predictive value of the selected biomarker set for HD group was 78%, with 82% sensitivity and 53% specificity. Further gene expression analyses in longitudinal studies are needed to validate and refine possible transcriptomic blood biomarkers in HD.

Original languageEnglish (US)
Pages (from-to)2277-2281
Number of pages5
JournalMovement Disorders
Volume24
Issue number15
DOIs
StatePublished - Nov 15 2009

Keywords

  • Biomarkers
  • Gene expression
  • Huntington's disease
  • Neurodegeneration
  • Transcriptomics

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Lovrecic, L., Kastrin, A., Kobal, J., Pirtosek, Z., Krainc, D., & Peterlin, B. (2009). Gene expression changes in blood as a putative biomarker for Huntington's disease. Movement Disorders, 24(15), 2277-2281. https://doi.org/10.1002/mds.22477