Abstract
Exposure to alcohol during early embryonic or fetal development has been linked with a variety of adverse outcomes, the most common of which are structural and functional abnormalities of the central nervous system [1]. Behavioural and cognitive deficits reported in individuals exposed to alcohol in utero include intellectual impairment, learning and memory difficulties, diminished executive functioning, attention problems, poor motor function and hyperactivity [2]. The economic and social costs of these outcomes are substantial and profound [3,4]. Improvement of neurobehavioural outcomes following prenatal alcohol exposure requires greater understanding of the mechanisms of alcohol-induced damage to the brain. Here we use a mouse model of relatively moderate ethanol exposure early in pregnancy and profile gene expression in the hippocampus and caudate putamen of adult male offspring. The effects of offspring sex and age on ethanol-sensitive hippocampal gene expression were also examined. All array data are available at the Gene Expression Omnibus (GEO) repository under accession number GSE87736.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 107-108 |
| Number of pages | 2 |
| Journal | Genomics Data |
| Volume | 10 |
| DOIs | |
| State | Published - Dec 2016 |
Funding
This work was supported by an Australian National Health and Medical Research Council grant ( 1003038 ) and an Australian Research Council Future Fellowship ( FT100100333 ) to SC. CZ was supported by scholarships from The University of Queensland and Mater Research . This work was also supported by funding from the Mater Foundation ( 4509 ). The Translational Research Institute is supported by a grant from the Australian Government .
Keywords
- Alcohol exposure
- Caudate putamen
- Gene expression
- Hippocampus
ASJC Scopus subject areas
- Biotechnology
- Biochemistry
- Molecular Medicine
- Genetics