Gene expression profiling of the aging mouse cardiac myocytes

Natalya Bodyak, Peter M. Kang, Makoto Hiromura, Indra Sulijoadikusumo, Nobuo Horikoshi, Konstantin Khrapko, Anny Usheva*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

71 Scopus citations

Abstract

Heart disease remains the most frequent cause of death in the general population with increasing incidence in the elderly population. The pathologic failure of the aging heart may be related to structural and functional alterations in cardiac muscle cells. However, the molecular mechanisms underlying the aging-related decline in cardiac muscle function are largely unknown. To provide the first analysis of cardiac aging at the level of gene expression, we established and compared cDNA libraries from apparently healthy young and aged mouse ventricular cardiac muscle cells. We report the identification of genes that exhibit aging-related changes of mRNA levels. Aging expression profiles in aged hearts indicate decreased cellular adaptation and protection against stress-induced injury together with the development of contractile dysfunction. The data suggest reduced activity of the mitochondrial electron transport system and reduced levels of cardiac-specific transcription regulators. The cardiomyocyte aging profile of gene expression displays similarities with known heart disorders. Genes whose mRNA levels change with aging in cardiomyocytes might profoundly affect pathological changes in the heart.

Original languageEnglish (US)
Pages (from-to)3788-3794
Number of pages7
JournalNucleic acids research
Volume30
Issue number17
DOIs
StatePublished - Sep 1 2002

ASJC Scopus subject areas

  • Genetics

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