Gene order and dynamic domains

Steven T. Kosak, Mark Groudine*

*Corresponding author for this work

Research output: Contribution to journalReview article

106 Scopus citations

Abstract

When considering the daunting complexity of eukaryotic genomes, some comfort can be found in the fact that the human genome may contain only 30,000 to 40,000 genes. Moreover, growing evidence suggests that genomes may be organized in such a way as to take advantage of space. A gene's Location in the Linear DNA sequence and its position in the three-dimensional nucleus can both be important in its regulation. Contrary to prevailing notions in this postgenomic era, the bacteriophage λ, a paragon of simplicity, may still have a few things to teach us with respect to these facets of nonrandom genomes.

Original languageEnglish (US)
Pages (from-to)644-647
Number of pages4
JournalScience
Volume306
Issue number5696
DOIs
StatePublished - Oct 22 2004

ASJC Scopus subject areas

  • General

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