Gene positioning and expression

Defne Egecioglu, Jason H. Brickner*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

59 Scopus citations

Abstract

Within the nucleus, the genome is spatially organized. Individual chromosomes are non-randomly positioned with respect to each other and with respect to nuclear landmarks [. 1,2]. Furthermore, the position of individual genes can reflect their expression. Here we discuss two well-characterized examples of gene relocalization associated with transcriptional activation: 1) developmentally regulated genes that move from the nuclear periphery to transcription factories in the nucleoplasm upon induction and 2) genes that are targeted from the nucleoplasm to the nuclear periphery, through interactions with the nuclear pore complex (NPC), upon activation. Finally, we speculate as to the mechanistic and functional commonalities of these phenomena.

Original languageEnglish (US)
Pages (from-to)338-345
Number of pages8
JournalCurrent Opinion in Cell Biology
Volume23
Issue number3
DOIs
StatePublished - Jun 2011

ASJC Scopus subject areas

  • Cell Biology

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