Gene positioning is regulated by phosphorylation of the nuclear pore complex by Cdk1

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6 Scopus citations


In yeast, many genes are targeted to the nuclear periphery through interaction with the Nuclear Pore Complex upon activation. Targeting requires nucleoporin proteins and DNA elements in the promoters of these genes. We have recently found that targeting is regulated through the cell cycle. Immediately following the initiation of DNA replication, active genes lose peripheral localization for ~30 minutes. This regulation is mediated by cyclic phosphorylation of a nucleoporin by Cdk1. Some genes that are targeted to the nuclear periphery upon activation remain at the nuclear periphery after repression, a phenomenon called transcriptional memory. Curiously, the mechanism that regulates localization of active genes to the nuclear periphery does not regulate the localization of the same genes after repression, suggesting that these genes are targeted by two distinct mechanisms. Finally, the localization of other parts of the genome at the nuclear periphery seems to be regulated by a distinct mechanism, suggesting that the spatial organization of the genome is coordinated with the progression of the cell cycle.

Original languageEnglish (US)
Pages (from-to)392-395
Number of pages4
JournalCell Cycle
Issue number3
StatePublished - Feb 1 2011


  • Cyclin dependent kinase
  • DNA replication
  • Nuclear architecture
  • Nuclear pore complex
  • Nucleus
  • Transcription

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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