Gene Regulation and Cellular Metabolism: An Essential Partnership

Richard W. Carthew*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations


It is recognized that cell metabolism is tightly connected to other cellular processes such as regulation of gene expression. Metabolic pathways not only provide the precursor molecules necessary for gene expression, but they also provide ATP, the primary fuel driving gene expression. However, metabolic conditions are highly variable since nutrient uptake is not a uniform process. Thus, cells must continually calibrate gene expression to their changing metabolite and energy budgets. This review discusses recent advances in understanding the molecular and biophysical mechanisms that connect metabolism and gene regulation as cells navigate their growth, proliferation, and differentiation. Particular focus is given to these mechanisms in the context of organismal development.

Original languageEnglish (US)
Pages (from-to)389-400
Number of pages12
JournalTrends in Genetics
Issue number4
StatePublished - Apr 2021


  • ATP
  • gene regulation
  • glucose metabolism

ASJC Scopus subject areas

  • Genetics


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