Gene Regulation and Cellular Metabolism: An Essential Partnership

Richard W. Carthew

doi:10.1016/j.tig.2020.09.018

Gene Regulation and Cellular Metabolism: An Essential Partnership

Richard W. Carthew^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

It is recognized that cell metabolism is tightly connected to other cellular processes such as regulation of gene expression. Metabolic pathways not only provide the precursor molecules necessary for gene expression, but they also provide ATP, the primary fuel driving gene expression. However, metabolic conditions are highly variable since nutrient uptake is not a uniform process. Thus, cells must continually calibrate gene expression to their changing metabolite and energy budgets. This review discusses recent advances in understanding the molecular and biophysical mechanisms that connect metabolism and gene regulation as cells navigate their growth, proliferation, and differentiation. Particular focus is given to these mechanisms in the context of organismal development.

Original language	English (US)
Journal	Trends in Genetics
DOIs	https://doi.org/10.1016/j.tig.2020.09.018
State	Accepted/In press - 2020

Keywords

ATP
gene regulation
glucose metabolism

ASJC Scopus subject areas

Genetics

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title = "Gene Regulation and Cellular Metabolism: An Essential Partnership",

abstract = "It is recognized that cell metabolism is tightly connected to other cellular processes such as regulation of gene expression. Metabolic pathways not only provide the precursor molecules necessary for gene expression, but they also provide ATP, the primary fuel driving gene expression. However, metabolic conditions are highly variable since nutrient uptake is not a uniform process. Thus, cells must continually calibrate gene expression to their changing metabolite and energy budgets. This review discusses recent advances in understanding the molecular and biophysical mechanisms that connect metabolism and gene regulation as cells navigate their growth, proliferation, and differentiation. Particular focus is given to these mechanisms in the context of organismal development.",

keywords = "ATP, gene regulation, glucose metabolism",

author = "Carthew, {Richard W.}",

note = "Funding Information: I would like to thank the National Institutes of Health (NIH) for financial support (R35GM118144). I would like to thank my colleagues in the NSF-Simons Center for Quantitative Biology for stimulating discussions and reading drafts of the manuscript. Funding Information: I would like to thank the National Institutes of Health (NIH) for financial support ( R35GM118144 ). I would like to thank my colleagues in the NSF-Simons Center for Quantitative Biology for stimulating discussions and reading drafts of the manuscript.",

year = "2020",

doi = "10.1016/j.tig.2020.09.018",

language = "English (US)",

journal = "Trends in Genetics",

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T2 - An Essential Partnership

AU - Carthew, Richard W.

N1 - Funding Information: I would like to thank the National Institutes of Health (NIH) for financial support (R35GM118144). I would like to thank my colleagues in the NSF-Simons Center for Quantitative Biology for stimulating discussions and reading drafts of the manuscript. Funding Information: I would like to thank the National Institutes of Health (NIH) for financial support ( R35GM118144 ). I would like to thank my colleagues in the NSF-Simons Center for Quantitative Biology for stimulating discussions and reading drafts of the manuscript.

PY - 2020

Y1 - 2020

N2 - It is recognized that cell metabolism is tightly connected to other cellular processes such as regulation of gene expression. Metabolic pathways not only provide the precursor molecules necessary for gene expression, but they also provide ATP, the primary fuel driving gene expression. However, metabolic conditions are highly variable since nutrient uptake is not a uniform process. Thus, cells must continually calibrate gene expression to their changing metabolite and energy budgets. This review discusses recent advances in understanding the molecular and biophysical mechanisms that connect metabolism and gene regulation as cells navigate their growth, proliferation, and differentiation. Particular focus is given to these mechanisms in the context of organismal development.

AB - It is recognized that cell metabolism is tightly connected to other cellular processes such as regulation of gene expression. Metabolic pathways not only provide the precursor molecules necessary for gene expression, but they also provide ATP, the primary fuel driving gene expression. However, metabolic conditions are highly variable since nutrient uptake is not a uniform process. Thus, cells must continually calibrate gene expression to their changing metabolite and energy budgets. This review discusses recent advances in understanding the molecular and biophysical mechanisms that connect metabolism and gene regulation as cells navigate their growth, proliferation, and differentiation. Particular focus is given to these mechanisms in the context of organismal development.

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KW - gene regulation

KW - glucose metabolism

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