Abstract
It is recognized that cell metabolism is tightly connected to other cellular processes such as regulation of gene expression. Metabolic pathways not only provide the precursor molecules necessary for gene expression, but they also provide ATP, the primary fuel driving gene expression. However, metabolic conditions are highly variable since nutrient uptake is not a uniform process. Thus, cells must continually calibrate gene expression to their changing metabolite and energy budgets. This review discusses recent advances in understanding the molecular and biophysical mechanisms that connect metabolism and gene regulation as cells navigate their growth, proliferation, and differentiation. Particular focus is given to these mechanisms in the context of organismal development.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 389-400 |
| Number of pages | 12 |
| Journal | Trends in Genetics |
| Volume | 37 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 2021 |
Funding
I would like to thank the National Institutes of Health (NIH) for financial support (R35GM118144). I would like to thank my colleagues in the NSF-Simons Center for Quantitative Biology for stimulating discussions and reading drafts of the manuscript. I would like to thank the National Institutes of Health (NIH) for financial support ( R35GM118144 ). I would like to thank my colleagues in the NSF-Simons Center for Quantitative Biology for stimulating discussions and reading drafts of the manuscript.
Keywords
- ATP
- gene regulation
- glucose metabolism
ASJC Scopus subject areas
- Genetics