TY - JOUR
T1 - Gene regulation by microRNAs
AU - Carthew, Richard W.
N1 - Funding Information:
This work has been supported by the National Institutes of Health.
PY - 2006/4
Y1 - 2006/4
N2 - The role of small RNAs as key regulators of mRNA turnover and translation has been well established. Recent advances indicate that the small RNAs termed microRNAs play important roles in animal development and physiology. Cellular activities such as proliferation, morphogenesis, apoptosis and differentiation are regulated by microRNAs. The expression of various genes are regulated by microRNAs, and several microRNAs act in reciprocal negative feedback loops with protein factors to control cell fate decisions that are triggered by signal transduction activity. These observations implicate small RNAs as important mediators of gene regulation in response to cell-cell signaling. The mechanism by which microRNAs silence gene expression is post-transcriptional, possibly influencing the stability, compartmentalization and translation of mRNAs. This mechanism is an efficient means to regulate production of a diverse range of proteins.
AB - The role of small RNAs as key regulators of mRNA turnover and translation has been well established. Recent advances indicate that the small RNAs termed microRNAs play important roles in animal development and physiology. Cellular activities such as proliferation, morphogenesis, apoptosis and differentiation are regulated by microRNAs. The expression of various genes are regulated by microRNAs, and several microRNAs act in reciprocal negative feedback loops with protein factors to control cell fate decisions that are triggered by signal transduction activity. These observations implicate small RNAs as important mediators of gene regulation in response to cell-cell signaling. The mechanism by which microRNAs silence gene expression is post-transcriptional, possibly influencing the stability, compartmentalization and translation of mRNAs. This mechanism is an efficient means to regulate production of a diverse range of proteins.
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U2 - 10.1016/j.gde.2006.02.012
DO - 10.1016/j.gde.2006.02.012
M3 - Review article
C2 - 16503132
AN - SCOPUS:33644857025
VL - 16
SP - 203
EP - 208
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
SN - 0959-437X
IS - 2
ER -