Gene therapy progress and prospects: Viral trafficking during infection

E. M. Campbell, T. J. Hope*

*Corresponding author for this work

Research output: Contribution to journalReview article

41 Scopus citations

Abstract

The intracellular steps involved in viral infection, namely cytoplasmic trafficking and nuclear import, are critical events in the viral life cycle that have lagged behind other areas of viral research. This review examines recent advances in our understanding of these steps for viruses commonly employed as viral gene delivery vectors. Steps governing the cytoplasmic trafficking and nuclear import of Herpes Simplex virus, Human Immunodeficiency virus and Adenovirus are reviewed in this article.

Original languageEnglish (US)
Pages (from-to)1353-1359
Number of pages7
JournalGene therapy
Volume12
Issue number18
DOIs
StatePublished - Sep 1 2005

Keywords

  • Adenovirus
  • Cytoskeleton
  • HIV
  • HSV
  • Infection
  • Nuclear import
  • Trafficking
  • Virus

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics

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