TY - JOUR
T1 - General Principles and Pharmacology of Biologics in Inflammatory Bowel Disease
AU - Kozuch, Patricia L.
AU - Hanauer, Stephen B.
PY - 2006/12
Y1 - 2006/12
N2 - The pharmacology of each biologic agent is important regarding the dose required to achieve benefits, duration of therapeutic effect, and the induction of immunogenicity. Comprehension of the individual pharmacology, pharmacodynamics, and pharmacokinetics, in addition to the impact of concomitant immunomodulation on immunogenicity allows optimization of each biologic agent in the appropriate inductive or maintenance setting of IBD.
AB - The pharmacology of each biologic agent is important regarding the dose required to achieve benefits, duration of therapeutic effect, and the induction of immunogenicity. Comprehension of the individual pharmacology, pharmacodynamics, and pharmacokinetics, in addition to the impact of concomitant immunomodulation on immunogenicity allows optimization of each biologic agent in the appropriate inductive or maintenance setting of IBD.
UR - http://www.scopus.com/inward/record.url?scp=33751244213&partnerID=8YFLogxK
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U2 - 10.1016/j.gtc.2006.09.005
DO - 10.1016/j.gtc.2006.09.005
M3 - Review article
C2 - 17129812
AN - SCOPUS:33751244213
SN - 0889-8553
VL - 35
SP - 757
EP - 773
JO - Gastroenterology Clinics of North America
JF - Gastroenterology Clinics of North America
IS - 4
ER -
