Generation of effector CD8+ T cells and their conversion to memory T cells

Weiguo Cui, Susan M. Kaech

Research output: Contribution to journalReview articlepeer-review

205 Scopus citations

Abstract

Immunological memory is a cardinal feature of adaptive immunity. We are now beginning to elucidate the mechanisms that govern the formation of memory T cells and their ability to acquire longevity, survive the effector-to-memory transition, and mature into multipotent, functional memory T cells that self-renew. Here, we discuss the recent findings in this area and highlight extrinsic and intrinsic factors that regulate the cellular fate of activated CD8+ T cells.

Original languageEnglish (US)
Pages (from-to)151-166
Number of pages16
JournalImmunological Reviews
Volume236
Issue number1
DOIs
StatePublished - Jul 2010

Keywords

  • Cell differentiation
  • Memory
  • T cells
  • Transcription factors
  • Vaccination
  • Viral

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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