Generation of embryonic stem cells: Limitations of and alternatives to inner cell mass harvest

Sunit Das*, Michael Bonaguidi, Kenji Muro, John A. Kessler

*Corresponding author for this work

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Embryonic stem (ES) cells are pluripotent cells derived from the inner cell mass of the early mammalian embryo. Because of their plasticity and potentially unlimited capacity for self-renewal, ES cells have generated tremendous interest both as models for developmental biology and as possible tools for regenerative medicine. This excitement has been attenuated, however, by scientific, political, and ethical considerations. In this article the authors describe somatic cell nuclear transfer and transcription-induced pluripotency, 2 techniques that have been used in attempts to circumvent the need to derive ES cells by the harvest of embryonic tissue.

Original languageEnglish (US)
Article numberE3
JournalNeurosurgical focus
Volume24
Issue number3-4
DOIs
StatePublished - Mar 1 2008

Keywords

  • Blastocyst
  • Cell transplantation
  • Embryonic stem cell
  • Induced pluripotency
  • Inner cell mass
  • Somatic cell nuclear transfer

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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