Abstract
We have generated a human induced pluripotent stem cell (iPSC) line under feeder-free culture conditions using the urine derived cells (UCs) collected from subject with a novel homozygous Plasminogen Activator Inhibitor-1 (PAI-1 null) mutation. The Sendai virus (SeV) vector encoding pluripotent Yamanaka transcription factors was used at a low multiplicity of infection to reprogram the PAI-1 UCs.
Original language | English (US) |
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Pages (from-to) | 657-660 |
Number of pages | 4 |
Journal | Stem Cell Research |
Volume | 17 |
Issue number | 3 |
DOIs | |
State | Published - Nov 2016 |
Funding
This work was supported by the National Institutes of Health K08 grant number HL111148 (J.L.S.) and R01HL051387 (D.E.V.). We are especially indebted to patients and their families for participating in this study and donating samples.
ASJC Scopus subject areas
- Cell Biology
- Developmental Biology