Generation of human iPSCs from urine derived cells of patient with a novel heterozygous PAI-1 mutation

Muhammad Zeeshan Afzal, Melanie Gartz, Ekaterina A. Klyachko, Sadiya Sana Khan, Sanjiv J. Shah, Sweta Gupta, Amy D. Shapiro, Douglas E. Vaughan, Jennifer L. Strande*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

We have generated a human induced pluripotent stem cell (iPSC) line under feeder-free culture conditions using the urine derived cells (UCs) collected from subjects heterozygous for a novel Plasminogen Activator Inhibitor-1 (PAI-1) mutation. The Sendai Virus (SeV) vector encoding pluripotent Yamanaka transcription factors was used at a low multiplicity of infection to reprogram the PAI-1 UCs.

Original languageEnglish (US)
Pages (from-to)41-44
Number of pages4
JournalStem Cell Research
Volume18
DOIs
StatePublished - Jan 2017

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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