@inbook{e071d5a71a2c4cbd87876373a728a7ce,
title = "Generation of Phosphopeptide-Specific T Cell Lines as Tools for Melanoma Immunotherapy",
abstract = "The importance of tumor-associated antigen-specific T cells in the effective control of cancer has been highlighted by recent advances in cancer immunotherapies that target the programmed cell death-1 (PD-1) pathway or that utilize modified T cell receptors. Phosphopeptide-specific T cells are of interest because they recognize a new class of tumor antigens that are derived from proteins relevant for cancer development and growth. These T cell lines or their antigen receptors can be used in combination with other forms of therapy to improve the immune response and survival of cancer patients. We describe here a protocol for the generation of human and transgenic murine phosphopeptide-specific T cells lines as tools for investigating T cell reactivity against melanoma phosphoantigens displayed by HLA-A*0201.",
keywords = "Antigens, Immunotherapy, Phosphopeptides, T cell lines, T cell therapy",
author = "Obeng, {Rebecca C.} and Ambakhutwala, {Angela L.}",
note = "Publisher Copyright: {\textcopyright} 2021, Springer Science+Business Media, LLC, part of Springer Nature.",
year = "2021",
doi = "10.1007/978-1-0716-1205-7_45",
language = "English (US)",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "655--670",
booktitle = "Methods in Molecular Biology",
}
