Genetic admixture and asthma-related phenotypes in Mexican American and Puerto Rican asthmatics

Keyan Salari, Shweta Choudhry, Hua Tang, Mariam Naqvi, Denise Lind, Pedro C. Avila, Natasha E. Coyle, Ngim Ung, Sylvette Nazario, Jesus Casal, Alfonso Torres-Palacios, Suzanne Clark, Angie Phong, Ivan Gomez, Henry Matallana, Eliseo J. Pérez-Stable, Mark D. Shriver, Pui Yan Kwok, Dean Sheppard, William Rodriguez-CintronNeil J. Risch, Esteban González Burchard*, Elad Ziv

*Corresponding author for this work

Research output: Contribution to journalArticle

129 Scopus citations

Abstract

Genetic association studies in admixed populations may be biased if individual ancestry varies within the population and the phenotype of interest is associated with ancestry. However, recently admixed populations also offer potential benefits in association studies since markers informative for ancestry may be in linkage disequilibrium across large distances. In particular, the enhanced LD in admixed populations may be used to identify alleles that underlie a genetically determined difference in a phenotype between two ancestral populations. Asthma is known to have different prevalence and severity among ancestrally distinct populations. We investigated several asthma-related phenotypes in two ancestrally admixed populations: Mexican Americans and Puerto Ricans. We used ancestry informative markers to estimate the individual ancestry of 181 Mexican American asthmatics and 181 Puerto Rican asthmatics and tested whether individual ancestry is associated with any of these phenotypes independently of known environmental factors. We found an association between higher European ancestry and more severe asthma as measured by both forced expiratory volume at 1 second (r=-0.21, p=0.005) and by a clinical assessment of severity among Mexican Americans (OR: 1.55; 95% CI 1.25 to 1.93). We found no significant associations between ancestry and severity or drug responsiveness among Puerto Ricans. These results suggest that asthma severity may be influenced by genetic factors differentiating Europeans and Native Americans in Mexican Americans, although differing results for Puerto Ricans require further investigation.

Original languageEnglish (US)
Pages (from-to)76-86
Number of pages11
JournalGenetic Epidemiology
Volume29
Issue number1
DOIs
StatePublished - Jul 2005

Keywords

  • Admixture
  • Asthma
  • Hispanics/Latinos

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)

Fingerprint Dive into the research topics of 'Genetic admixture and asthma-related phenotypes in Mexican American and Puerto Rican asthmatics'. Together they form a unique fingerprint.

  • Cite this

    Salari, K., Choudhry, S., Tang, H., Naqvi, M., Lind, D., Avila, P. C., Coyle, N. E., Ung, N., Nazario, S., Casal, J., Torres-Palacios, A., Clark, S., Phong, A., Gomez, I., Matallana, H., Pérez-Stable, E. J., Shriver, M. D., Kwok, P. Y., Sheppard, D., ... Ziv, E. (2005). Genetic admixture and asthma-related phenotypes in Mexican American and Puerto Rican asthmatics. Genetic Epidemiology, 29(1), 76-86. https://doi.org/10.1002/gepi.20079