Genetic alterations affecting GTPases and T-cell receptor signaling in peripheral T-cell lymphomas

Rebecca L. Boddicker, Gina L. Razidlo, Andrew L. Feldman*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


Peripheral T-cell lymphomas (PTCLs) are rare, heterogeneous tumors with poor response to standard therapy and few targeted treatments available. The identification of mutations in the T-cell receptor (TCR) signaling pathway that either directly or indirectly affect Ras- and Rho-family GTPases is an emerging theme across PTCL subtypes. This review summarizes the role of GTPases in TCR signaling and highlights the constellation of mutations in this pathway among PTCLs. In particular, focus is given to the functional impact of the mutations and opportunities for targeted therapy. These mutations include activating mutations and gene fusions involving the guanine nucleotide exchange factor, VAV1, as well as activating and dominant negative mutations in the GTPases KRAS and RHOA, respectively. In addition to mutations directly affecting the GTPase pathway, TCR signaling mutations indirectly affecting Ras- and Rho-family GTPases involving genes such as CD28, FYN, LCK, and PLCG1 are also reviewed.

Original languageEnglish (US)
Pages (from-to)33-39
Number of pages7
JournalSmall GTPases
Issue number1
StatePublished - Jan 2 2019


  • GTPase
  • RAC1
  • RHOA
  • T cell signaling
  • VAV1
  • fusion protein
  • mutation
  • peripheral T-cell lymphoma

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology


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