Genetic analysis of susceptibility to Theiler's murine encephalomyelitis virus-induced demyelinating disease in the SWR strain

Simone M. Nicholson, Diane M. Jokinen, Mauro Carlo Dal Canto, Byung S Kim, Roger W. Melvold*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

SWR/J mice are susceptible to immune-mediated central (CNS) demyelination following infection by Theiler's murine encephalomyelitis virus (TMEV). SWR/J susceptibility is genetically dominant, when outcrossed to resistant H-2b strains. Non-H-2 differences between C57BL/6 and C57L/J (both H-2b) alter effects of 'susceptibility' genes, especially H-2q, from SWR/J. Genetic analysis of differential susceptibility to demyelination between SWR/J and C57L/J indicates that one copy of H-2q is sufficient for disease, and that SWR/J mice carry a non-H-2 gene which can lead to disease in the absence of H-2q. Differential susceptibility between SWR/J and C57BL/6 is determined by a single non-H-2 locus, which may or may not be the same as that differing between SWR/J and C57L/J.

Original languageEnglish (US)
Pages (from-to)19-28
Number of pages10
JournalJournal of Neuroimmunology
Volume59
Issue number1-2
DOIs
StatePublished - Jan 1 1995

Keywords

  • C57BL/6
  • C57L
  • Demyelinating disease
  • Multiple sclerosis
  • SWR
  • Theiler's murine encephalomyelitis virus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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