Genetic and epigenetic control of the spatial organization of the genome

Jason Brickner*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Eukaryotic genomes are spatially organized within the nucleus by chromosome folding, interchromosomal contacts, and interaction with nuclear structures. This spatial organization is observed in diverse organisms and both reflects and contributes to gene expression and differentiation. This leads to the notion that the arrangement of the genome within the nucleus has been shaped and conserved through evolutionary processes and likely plays an adaptive function. Both DNA-binding proteins and changes in chromatin structure influence the positioning of genes and larger domains within the nucleus. This suggests that the spatial organization of the genome can be genetically encoded by binding sites for DNA-binding proteins and can also involve changes in chromatin structure, potentially through nongenetic mechanisms. Here I briefly discuss the results that support these ideas and their implications for how genomes encode spatial organization.

Original languageEnglish (US)
Pages (from-to)364-369
Number of pages6
JournalMolecular biology of the cell
Issue number3
StatePublished - Feb 1 2017

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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