Genetic and Epigenetic Regulation of Human Cardiac Reprogramming and Differentiation in Regenerative Medicine

Paul W. Burridge, Arun Sharma, Joseph C. Wu

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Regeneration or replacement of lost cardiomyocytes within the heart has the potential to revolutionize cardiovascular medicine. Numerous methodologies have been used to achieve this aim, including the engraftment of bone marrow- and heart-derived cells as well as the identification of modulators of adult cardiomyocyte proliferation. Recently, the conversion of human somatic cells into induced pluripotent stem cells and induced cardiomyocyte-like cells has transformed potential approaches toward this goal, and the engraftment of cardiac progenitors derived from human embryonic stem cells into patients is now feasible. Here we review recent advances in our understanding of the genetic and epigenetic control of human cardiogenesis, cardiac differentiation, and the induced reprogramming of somatic cells to cardiomyocytes. We also cover genetic programs for inducing the proliferation of endogenous cardiomyocytes and discuss the genetic state of cells used in cardiac regenerative medicine.

Original languageEnglish (US)
Pages (from-to)461-484
Number of pages24
JournalAnnual Review of Genetics
Volume49
DOIs
StatePublished - Nov 23 2015

Keywords

  • Cardiomyocyte
  • Developmental biology
  • Embryonic stem cells
  • Epigenetics
  • Heart
  • Induced pluripotent stem cells

ASJC Scopus subject areas

  • Genetics

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