Genetic and epigenetic studies of amyotrophic lateral sclerosis

Ammar Al-Chalabi*, Shin Kwak, Mark Mehler, Guy Rouleau, Teepu Siddique, Michael Strong, Peter Nigel Leigh

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


The identification of genetic and epigenetic factors that are associated with an increased risk of developing amyotrophic lateral sclerosis (ALS), or that modify the age of onset or rate of progression, requires a multimodal research strategy, facilitated through international collaboration. The discovery of several ALS genes strongly linked to RNA biology, the proteasome pathway, and axonal transport suggest they have an important role in pathogenesis, but the immense complexity of these processes is also apparent. The increasing rate of genetic discoveries brings the hope of designing more targeted and efficacious therapies.

Original languageEnglish (US)
Pages (from-to)44-52
Number of pages9
JournalAmyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Issue numberSUPPL1
StatePublished - May 2013


  • ALS
  • Epigenetic
  • Familial ALS
  • Genetic
  • Modifier genes

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


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