Genetic approach to pediatric septic shock

Derek S. Wheeler, Hector R. Wong*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Septic shock is a complex and heterogeneous clinical syndrome, triggered by infection, and having significant morbidity and mortality in children. Emerging data indicate that the genetic make-up of the pediatric host may have a strong influence on the development and outcome of septic shock in children. Herein, we review this broad topic by focusing on pediatric-specific data (both recent and historical), as well as the broad topics of SNPs, genome-wide association studies and epigenetics. The historical and emerging data strongly suggest that a genetics-based perspective will need to be considered in future investigations and strategies aimed at improving the outcome of children with septic shock.

Original languageEnglish (US)
Pages (from-to)249-263
Number of pages15
JournalPersonalized Medicine
Volume5
Issue number3
DOIs
StatePublished - May 2008
Externally publishedYes

Keywords

  • Epigenetics
  • Genomics
  • Pediatrics
  • Sepsis
  • Single nucleotide polymorphisms

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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