Abstract
Leptin is abnormally elevated in the plasma of patients with systemic lupus erythematosus (SLE), where it is thought to promote and/or sustain pro-inflammatory responses. Whether this association could reflect an increased genetic susceptibility to develop SLE is not known, and studies of genetic associations with leptin-related polymorphisms in SLE patients have been so far inconclusive. Here we genotyped DNA samples from 15,706 SLE patients and healthy matched controls from four different ancestral groups, to correlate polymorphisms of genes of the leptin pathway to risk for SLE. It was found that although several SNPs showed weak associations, those associations did not remain significant after correction for multiple testing. These data do not support associations between defined leptin-related polymorphisms and increased susceptibility to develop SLE.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 157-162 |
| Number of pages | 6 |
| Journal | Clinical Immunology |
| Volume | 161 |
| Issue number | 2 |
| DOIs | |
| State | Published - Dec 1 2015 |
Funding
We thank all subjects for participation in this study, and Erika Magdangal for help with DNA preparation and organization. This work was supported by the US National Institutes of Health grants AR53239 (A.L.C.) AR043814 and AR065626 (B.P.T.), AI083194 (J.B.H., K.M.S., R.P.K., L.A.C., T.J.V., M.E.A.R., C.O.J., B.P.T. and P.M.G.), AR049084 (R.P.K., J.B.H., J.C.E., E.E.B., G.S.A., J.D.R., R.R.G. and M.A.P.), AR064820 (E.E.B., M.A.P., R.R.G., J.D.R. and L.M.V.), TR001417 (J.C.E. and R.P.K.), CA141700 and AR058621 (M.E.A.R.), AR053308 and TR000004 (L.A.C.), AR062755 and RR029882 (G.S.G. and D.L.K.), AR057172 (C.O.J.), GM103510 , GM104938 , AR053483 , AI101934 and AI082714 (J.A.J.), AI063274 (P.M.G.), AR043274 (K.M.S.), AI083790 , AI071651 and RR024999 (T.B.N.), AR43727 (M.A.P.), AR002138 , AR066464 and TR001422 (R.R.G.), RR023417 (J.D.R.), AR051545 and RR025014 (A.M.S.), AI070304 (S.A.B.), AR042460 , AR062277 , RR020143 and AI024717 (J.B.H.), AR048311 and AR055385 (E.E.B.), AR033062 (R.P.K.). Additional funds were from the Lupus Foundation of America (B.P.T.), the Alliance for Lupus Research (B.P.T., Y.D., K.M.S., T.B.N., L.A.C., C.O.J. and S.A.B.), the Lupus Research Institute (B.P.T. and T.B.N.), the US Department of Veterans Affairs (Merit Awards; J.B.H. and G.S.G.), the US Department of Defense ( PR094002 , J.B.H.), the Arthritis National Research Foundation (Eng Tan Scholar Award; J.Z. and T.B.N.), the Arthritis Foundation (A.M.S. and P.M.G.), the Korea Healthcare Technology R&D Project , Ministry for Health and Welfare, Republic of Korea ( HI13C2124 to S.C.B and HI13C1754 and HI14C1277 to Y.W.S.), the European Science Foundation RNP (BIOLUPUS Research Network), the Wellcome Trust (T.J.V.), Arthritis Research UK (T.J.V.), a Kirkland Scholar Award (L.A.C.), the Wake Forest School of Medicine Center for Public Health Genomics (C.D.L.), and UCLA Clinical and Translational Science Institute (CTSI) RR033176 and TR000124 .
Keywords
- Gene polymorphisms
- Leptin pathway
- Systemic lupus erythematosus
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology