Genetic basis for skin youthfulness

Kelsey S. Flood, Neil A. Houston, Kevin T. Savage, Alexa B. Kimball*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Aging skin is a consequence of both intrinsic factors, including genetics, and extrinsic factors, including environmental exposures such as ultraviolet (UV) radiation and smoking. This contribution focuses on intrinsic factors that promote aging skin. Specifically, in this contribution we review the literature describing how single nucleotide polymorphisms, epigenetic changes, variable gene expression, microRNA, and mitochondrial depletion relate to skin aging. Investigations studying intrinsic factors associated with skin aging are important as they promote a better understanding of the underlying pathophysiology of aging skin. This contribution also describes potential avenues for future genetic research in skin aging. Molecular mechanisms that may be therapeutically intervened upon are of particular interest given the cultural value placed on youthful appearing skin. Future research efforts will hopefully reveal a means upon which to intercede on the skin aging process.

Original languageEnglish (US)
Pages (from-to)312-319
Number of pages8
JournalClinics in Dermatology
Issue number4
StatePublished - Jul 1 2019

ASJC Scopus subject areas

  • Dermatology


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