Genetic basis of familial amyotrophic lateral sclerosis

R. Eldridge, C. Alberstone, M. A. Meyer, T. Siddique, R. H. Brown

Research output: Contribution to journalLetterpeer-review

4 Scopus citations


To the Editor: Conneally has presented an informative discussion of the implications of the detection of markers for a major gene (May 16 issue).1 The immediate stimulus was the report by Siddique et al. in the same issue of four DNA markers on the long arm of chromosome 4 that, in a subgroup of families, were linked to the familial form of amyotrophic lateral sclerosis.2 In sharing with us some of the background of the study, Conneally points out that a simple but highly unusual step was critical to its success — the decision by two competing groups of investigators.

Original languageEnglish (US)
Pages (from-to)1382-1383
Number of pages2
JournalNew England Journal of Medicine
Issue number19
StatePublished - Nov 7 1991

ASJC Scopus subject areas

  • General Medicine


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