Genetic control of serotonin uptake in blood platelets: A twin study

Herbert Y. Meltzer*, Ramesh C. Arora

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


Platelet serotonin (5HT) uptake was studied in 13 pairs of monozygotic (MZ) twins, 13 pairs of dizygotic (DZ) twins, and 14 pairs of unrelated normal volunteers. Significant intraclass correlations (ICC) in the affinity (Km) of 5HT uptake in the blood platelets of MZ and DZ twins and unrelated pairs were found. However, the ICC for maximum velocity (Vmax) was significant only in MZ and DZ twins. The ICC of the Vmax of 5HT uptake of MZ twins was significantly greater than that of DZ twins and unrelated pairs. This suggests that the Vmax of 5HT uptake in blood platelets is, in part, heritable. Thus, low platelet 5HT uptake (Vmax) in major depression and other disorders may be genetically determined.

Original languageEnglish (US)
Pages (from-to)263-269
Number of pages7
JournalPsychiatry Research
Issue number3
StatePublished - Jun 1988


  • Serotonin uptake
  • depression
  • monozygotic and dizygotic twins

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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