Genetic control of serotonin uptake in blood platelets: A twin study

Herbert Y. Meltzer; Ramesh C. Arora

doi:10.1016/0165-1781(88)90108-4

Genetic control of serotonin uptake in blood platelets: A twin study

Herbert Y. Meltzer^*, Ramesh C. Arora

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

Platelet serotonin (5HT) uptake was studied in 13 pairs of monozygotic (MZ) twins, 13 pairs of dizygotic (DZ) twins, and 14 pairs of unrelated normal volunteers. Significant intraclass correlations (ICC) in the affinity (K_m) of 5HT uptake in the blood platelets of MZ and DZ twins and unrelated pairs were found. However, the ICC for maximum velocity (V_max) was significant only in MZ and DZ twins. The ICC of the V_max of 5HT uptake of MZ twins was significantly greater than that of DZ twins and unrelated pairs. This suggests that the V_max of 5HT uptake in blood platelets is, in part, heritable. Thus, low platelet 5HT uptake (V_max) in major depression and other disorders may be genetically determined.

Original language	English (US)
Pages (from-to)	263-269
Number of pages	7
Journal	Psychiatry Research
Volume	24
Issue number	3
DOIs	https://doi.org/10.1016/0165-1781(88)90108-4
State	Published - Jun 1988

Keywords

Serotonin uptake
depression
monozygotic and dizygotic twins

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/0165-1781(88)90108-4

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@article{87d71a4e55ba41b6a44b8f21c2995993,

title = "Genetic control of serotonin uptake in blood platelets: A twin study",

abstract = "Platelet serotonin (5HT) uptake was studied in 13 pairs of monozygotic (MZ) twins, 13 pairs of dizygotic (DZ) twins, and 14 pairs of unrelated normal volunteers. Significant intraclass correlations (ICC) in the affinity (Km) of 5HT uptake in the blood platelets of MZ and DZ twins and unrelated pairs were found. However, the ICC for maximum velocity (Vmax) was significant only in MZ and DZ twins. The ICC of the Vmax of 5HT uptake of MZ twins was significantly greater than that of DZ twins and unrelated pairs. This suggests that the Vmax of 5HT uptake in blood platelets is, in part, heritable. Thus, low platelet 5HT uptake (Vmax) in major depression and other disorders may be genetically determined.",

keywords = "Serotonin uptake, depression, monozygotic and dizygotic twins",

author = "Meltzer, {Herbert Y.} and Arora, {Ramesh C.}",

note = "Funding Information: Acknowledgments. The research reported was supported, in part, by USPHS M H-30059, MH-41684, MH111594, and by the Cleveland Foundation. H.Y.M. is recipient of USPHS Research Career Scientist Award 47808. We are grateful to Ms. L. Kregel for laboratory",

year = "1988",

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doi = "10.1016/0165-1781(88)90108-4",

language = "English (US)",

volume = "24",

pages = "263--269",

journal = "Psychiatry Research",

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T1 - Genetic control of serotonin uptake in blood platelets

T2 - A twin study

AU - Meltzer, Herbert Y.

AU - Arora, Ramesh C.

N1 - Funding Information: Acknowledgments. The research reported was supported, in part, by USPHS M H-30059, MH-41684, MH111594, and by the Cleveland Foundation. H.Y.M. is recipient of USPHS Research Career Scientist Award 47808. We are grateful to Ms. L. Kregel for laboratory

PY - 1988/6

Y1 - 1988/6

N2 - Platelet serotonin (5HT) uptake was studied in 13 pairs of monozygotic (MZ) twins, 13 pairs of dizygotic (DZ) twins, and 14 pairs of unrelated normal volunteers. Significant intraclass correlations (ICC) in the affinity (Km) of 5HT uptake in the blood platelets of MZ and DZ twins and unrelated pairs were found. However, the ICC for maximum velocity (Vmax) was significant only in MZ and DZ twins. The ICC of the Vmax of 5HT uptake of MZ twins was significantly greater than that of DZ twins and unrelated pairs. This suggests that the Vmax of 5HT uptake in blood platelets is, in part, heritable. Thus, low platelet 5HT uptake (Vmax) in major depression and other disorders may be genetically determined.

AB - Platelet serotonin (5HT) uptake was studied in 13 pairs of monozygotic (MZ) twins, 13 pairs of dizygotic (DZ) twins, and 14 pairs of unrelated normal volunteers. Significant intraclass correlations (ICC) in the affinity (Km) of 5HT uptake in the blood platelets of MZ and DZ twins and unrelated pairs were found. However, the ICC for maximum velocity (Vmax) was significant only in MZ and DZ twins. The ICC of the Vmax of 5HT uptake of MZ twins was significantly greater than that of DZ twins and unrelated pairs. This suggests that the Vmax of 5HT uptake in blood platelets is, in part, heritable. Thus, low platelet 5HT uptake (Vmax) in major depression and other disorders may be genetically determined.

KW - Serotonin uptake

KW - depression

KW - monozygotic and dizygotic twins

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JO - Psychiatry Research

JF - Psychiatry Research

SN - 0165-1781

IS - 3

ER -

Genetic control of serotonin uptake in blood platelets: A twin study

Abstract

Keywords

ASJC Scopus subject areas

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