Genetic disorders of motor neurons

N. Cole, T. Siddique*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations

Abstract

Disorders of the motor neuron are etiologically and clinically heterogeneous and cause serious disability and death. Whereas mendelian inheritance can be demonstrated in a subset of these disorders, the genetic contribution to the sporadic forms of motor neuron degeneration are not well understood. In families with spinal muscular atrophy, Kennedy disease and amyotrophic lateral sclerosis, genetic linkage analysis and positional cloning have proven to be extremely productive. The genetics of these neurodegenerative disorders are reviewed.

Original languageEnglish (US)
Pages (from-to)407-418
Number of pages12
JournalSeminars in Neurology
Volume19
Issue number4
DOIs
StatePublished - Jan 1 1999

Keywords

  • Amyotrophic lateral sclerosis
  • Genes
  • Genetics
  • Kennedy disease
  • Motor neuron disorders
  • Neurodegeneration
  • Spinal muscular atrophy

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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