TY - JOUR
T1 - Genetic Immunodeficiency Diseases
AU - Abrams, Melissa
AU - Paller, Amy
PY - 2007/11/16
Y1 - 2007/11/16
N2 - The approach to the patient with genetic immunodeficiency is multidisciplinary, and requires close interaction between the primary care physician, immunologist, and other specialists. Dermatologists may play a key role in both the diagnosis of immunodeficiency based on recurrent infection or specific cutaneous abnormalities and in the management of cutaneous complications. The availability of bone marrow and stem cell transplantation has been life-saving for many affected children. The underlying genetic basis is now known for most forms of immunodeficiency, which has facilitated confirmation of patient diagnosis and prenatal diagnosis. Gene therapy has already been initiated for severe combined immunodeficiency, and will certainly play a growing role in therapy of this group of disorders in the future.
AB - The approach to the patient with genetic immunodeficiency is multidisciplinary, and requires close interaction between the primary care physician, immunologist, and other specialists. Dermatologists may play a key role in both the diagnosis of immunodeficiency based on recurrent infection or specific cutaneous abnormalities and in the management of cutaneous complications. The availability of bone marrow and stem cell transplantation has been life-saving for many affected children. The underlying genetic basis is now known for most forms of immunodeficiency, which has facilitated confirmation of patient diagnosis and prenatal diagnosis. Gene therapy has already been initiated for severe combined immunodeficiency, and will certainly play a growing role in therapy of this group of disorders in the future.
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U2 - 10.1016/j.yadr.2007.08.001
DO - 10.1016/j.yadr.2007.08.001
M3 - Review article
C2 - 18159903
AN - SCOPUS:36049027745
VL - 23
SP - 197
EP - 229
JO - Advances in Dermatology
JF - Advances in Dermatology
SN - 0882-0880
ER -