Genetic manipulation of mice to study cardiovascular disease

Susan E. Quaggin*, Anna Chan, Andras Nagy

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Cardiovascular disease is the leading cause of death for both men and women in North America. Endothelial dysfunction plays a major part in the pathogenesis and progression of vascular disease. Therapeutic interventions that deliver vascular endothelial growth factor (VEGF) to hypoxic tissues have shown great promise in patients with cardiac or peripheral vascular disease by enabling the growth of new blood vessels. By contrast, production of VEGF by solid tumours induces neovascularization required for tumour growth. Given these results, it is no surprise that VEGF has received great attention in the fight against cancer. Currently, there are 33 active clinical trials using anti-VEGF approaches in attempts to cure this disease. The VEGF gene (Gen-Bank accession number NM_003376; gene ID: 7422) is complex and produces numerous isoforms that carry different biological properties. Understanding the mechanism(s) of production, storage, delivery and function of VEGF is fundamental if we are to use this factor effectively in treating patients.

Original languageEnglish (US)
Pages (from-to)243-248
Number of pages6
JournalDrug Discovery Today: Disease Models
Volume1
Issue number3
DOIs
StatePublished - Dec 17 2004

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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