Genetic modifiers affecting severity of epilepsy caused by mutation of sodium channel Scn2a

Keyphrases

• Epilepsy 100%
• Genetic Modifiers 100%
• Sodium Channel 100%
• SCN2A 100%
• Clinical Severity 50%
• C57BL 33%
• Variable Expressivity 33%
• Epilepsy Phenotype 33%
• Partial Seizures 33%
• Human Epilepsy 16%
• Mouse Model 16%
• Hippocampus 16%
• Family Members 16%
• Transgenic Mouse Model 16%
• Genetic Background 16%
• Modifier Genes 16%
• Chromosome 11 16%
• Voltage-gated Sodium Channel 16%
• Modifier Loci 16%
• SCN1A 16%
• Chromosome 19 16%
• Long-term Survival 16%
• Clinical Manifestations 16%
• Epilepsy Patients 16%
• Spontaneous Seizures 16%
• Seizure Onset 16%
• Acquired Epilepsy 16%
• Sodium Channel mutation 16%
• Congenic 16%
• Generalized Seizures 16%
• Channel Inactivation 16%
• Backcross 16%
• Interval Mapping 16%
• Modifier Alleles 16%

Biochemistry, Genetics and Molecular Biology

• Genetics 100%
• Sodium Channel 100%
• Mouse Model 50%
• Congenic 25%
• Transgenic Mouse 25%
• Allele 25%
• Electric Potential 25%
• Chromosome 19 25%
• Modifier Gene 25%
• Chromosome 11 25%
• Genetic Background 25%

Neuroscience

• Sodium Channel 100%
• Partial Seizure 66%
• Hippocampus 33%
• Chromosome 11 33%
• Voltage Gated Sodium Channel 33%
• Chromosome 19 33%
• Modifier Gene 33%
• Sodium Channel Nav1.1 33%
• Sodium Channel Nav1.2 33%
• Tonic-Clonic Seizure 33%