Genetic modifiers of neurological disease

Jennifer A. Kearney

doi:10.1016/j.gde.2010.12.007

Genetic modifiers of neurological disease

Jennifer A. Kearney^*

^*Corresponding author for this work

Pharmacology

Research output: Contribution to journal › Review article › peer-review

24 Scopus citations

Abstract

Genetic modifiers make an important contribution to neurological disease phenotypes. Significant progress has been made by studying genetic modifiers in model organisms. The ability to study complex genetic interactions in model systems contributes to our understanding of the genetic factors that influence neurological disease. This will lead to the development of novel therapeutic strategies and personalized treatment based on genetic risk.

Original language	English (US)
Pages (from-to)	349-353
Number of pages	5
Journal	Current Opinion in Genetics and Development
Volume	21
Issue number	3
DOIs	https://doi.org/10.1016/j.gde.2010.12.007
State	Published - Jun 2011

ASJC Scopus subject areas

Genetics
Developmental Biology

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title = "Genetic modifiers of neurological disease",

abstract = "Genetic modifiers make an important contribution to neurological disease phenotypes. Significant progress has been made by studying genetic modifiers in model organisms. The ability to study complex genetic interactions in model systems contributes to our understanding of the genetic factors that influence neurological disease. This will lead to the development of novel therapeutic strategies and personalized treatment based on genetic risk.",

author = "Kearney, {Jennifer A.}",

note = "Funding Information: Thanks to Nicole Hawkins and Benjamin Jorge for critical reading of the manuscript. Related work in my laboratory is supported by NIH grants NS-053792 and NS063097 . ",

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N2 - Genetic modifiers make an important contribution to neurological disease phenotypes. Significant progress has been made by studying genetic modifiers in model organisms. The ability to study complex genetic interactions in model systems contributes to our understanding of the genetic factors that influence neurological disease. This will lead to the development of novel therapeutic strategies and personalized treatment based on genetic risk.

AB - Genetic modifiers make an important contribution to neurological disease phenotypes. Significant progress has been made by studying genetic modifiers in model organisms. The ability to study complex genetic interactions in model systems contributes to our understanding of the genetic factors that influence neurological disease. This will lead to the development of novel therapeutic strategies and personalized treatment based on genetic risk.

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Genetic modifiers of neurological disease

Abstract

ASJC Scopus subject areas

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