Genetic pathways leading to therapy-related myeloid neoplasms

Angela Stoddart, Megan E. McNerney, Elizabeth Bartom, Rachel Bergerson, David J. Young, Zhijian Qian, Jianghong Wang, Anthony A. Fernald, Elizabeth M. Davis, Richard A. Larson, Kevin P. White, Michelle M. Le Beau*

*Corresponding author for this work

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Therapy-related myeloid neoplasm (t-MN) is a distinctive clinical syndrome occurring after exposure to chemotherapy or radiotherapy. t-MN arises in most cases from a multipotential hematopoietic stem cell or, less commonly, in a lineage committed progenitor cell. The prognosis for patients with t-MN is poor, as current forms of therapy are largely ineffective. Cytogenetic analysis, molecular analysis and gene expression profiling analysis of t-MN has revealed that there are distinct subtypes of the disease; however, our understanding of the genetic basis of t-MN is incomplete. Elucidating the genetic pathways and molecular networks that are perturbed in t-MNs, may facilitate the identification of therapeutic targets that can be exploited for the development of urgently-needed targeted therapies.

Original languageEnglish (US)
Article numbere2011019
JournalMediterranean Journal of Hematology and Infectious Diseases
Volume3
Issue number1
DOIs
StatePublished - Jan 1 2011

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ASJC Scopus subject areas

  • Hematology
  • Infectious Diseases

Cite this

Stoddart, A., McNerney, M. E., Bartom, E., Bergerson, R., Young, D. J., Qian, Z., Wang, J., Fernald, A. A., Davis, E. M., Larson, R. A., White, K. P., & Le Beau, M. M. (2011). Genetic pathways leading to therapy-related myeloid neoplasms. Mediterranean Journal of Hematology and Infectious Diseases, 3(1), [e2011019]. https://doi.org/10.4084/MJHID.2011.019