Genetic polymorphisms and traumatic brain injury: the contribution of individual differences to recovery

Starla M. Weaver*, Jaclyn N. Portelli, Aileen Chau, Irene Cristofori, Laura Moretti, Jordan Grafman

*Corresponding author for this work

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Recovery after Traumatic Brain Injury (TBI) is variable, even for patients with similar severity of brain injury. Recent research has highlighted the contribution that genetic predisposition plays in determining TBI outcome. This review considers the potential for genetic polymorphisms to influence recovery of cognitive and social processes following TBI. Limitations and considerations that researchers should make when assessing the potential impact of polymorphisms on TBI outcome are also discussed. Understanding the genetic factors that support neuroplasticity will contribute to an understanding of the variation in outcome following injury and help to identify potential targets for rehabilitation.

Original languageEnglish (US)
Pages (from-to)420-434
Number of pages15
JournalBrain Imaging and Behavior
Volume8
Issue number3
DOIs
StatePublished - Aug 1 2014

Keywords

  • Genetic polymorphisms
  • Polymorphisms
  • Traumatic brain injury

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Cognitive Neuroscience
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health
  • Behavioral Neuroscience

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