Genetic polymorphisms and traumatic brain injury: the contribution of individual differences to recovery

Starla M. Weaver; Jaclyn N. Portelli; Aileen Chau; Irene Cristofori; Laura Moretti; Jordan Grafman

doi:10.1007/s11682-012-9197-9

Genetic polymorphisms and traumatic brain injury: the contribution of individual differences to recovery

Starla M. Weaver^*, Jaclyn N. Portelli, Aileen Chau, Irene Cristofori, Laura Moretti, Jordan Grafman

^*Corresponding author for this work

Physical Medicine and Rehabilitation

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Recovery after Traumatic Brain Injury (TBI) is variable, even for patients with similar severity of brain injury. Recent research has highlighted the contribution that genetic predisposition plays in determining TBI outcome. This review considers the potential for genetic polymorphisms to influence recovery of cognitive and social processes following TBI. Limitations and considerations that researchers should make when assessing the potential impact of polymorphisms on TBI outcome are also discussed. Understanding the genetic factors that support neuroplasticity will contribute to an understanding of the variation in outcome following injury and help to identify potential targets for rehabilitation.

Original language	English (US)
Pages (from-to)	420-434
Number of pages	15
Journal	Brain Imaging and Behavior
Volume	8
Issue number	3
DOIs	https://doi.org/10.1007/s11682-012-9197-9
State	Published - Aug 1 2014

Keywords

Genetic polymorphisms
Polymorphisms
Traumatic brain injury

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Neurology
Cognitive Neuroscience
Clinical Neurology
Cellular and Molecular Neuroscience
Psychiatry and Mental health
Behavioral Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s11682-012-9197-9

Cite this

@article{8007daa428a048ef822e52af98eb77dc,

title = "Genetic polymorphisms and traumatic brain injury: the contribution of individual differences to recovery",

abstract = "Recovery after Traumatic Brain Injury (TBI) is variable, even for patients with similar severity of brain injury. Recent research has highlighted the contribution that genetic predisposition plays in determining TBI outcome. This review considers the potential for genetic polymorphisms to influence recovery of cognitive and social processes following TBI. Limitations and considerations that researchers should make when assessing the potential impact of polymorphisms on TBI outcome are also discussed. Understanding the genetic factors that support neuroplasticity will contribute to an understanding of the variation in outcome following injury and help to identify potential targets for rehabilitation.",

keywords = "Genetic polymorphisms, Polymorphisms, Traumatic brain injury",

author = "Weaver, {Starla M.} and Portelli, {Jaclyn N.} and Aileen Chau and Irene Cristofori and Laura Moretti and Jordan Grafman",

note = "Funding Information: The preparation of this article was supported by funding from the Kessler Foundation. Portions of this manuscript were previously published (Weaver , Chau, Portelli & Grafman, in press). Publisher Copyright: {\textcopyright} 2012, Springer Science+Business Media, LLC.",

year = "2014",

month = aug,

day = "1",

doi = "10.1007/s11682-012-9197-9",

language = "English (US)",

volume = "8",

pages = "420--434",

journal = "Brain Imaging and Behavior",

issn = "1931-7557",

publisher = "Springer New York",

number = "3",

}

TY - JOUR

T1 - Genetic polymorphisms and traumatic brain injury

T2 - the contribution of individual differences to recovery

AU - Weaver, Starla M.

AU - Portelli, Jaclyn N.

AU - Chau, Aileen

AU - Cristofori, Irene

AU - Moretti, Laura

AU - Grafman, Jordan

N1 - Funding Information: The preparation of this article was supported by funding from the Kessler Foundation. Portions of this manuscript were previously published (Weaver , Chau, Portelli & Grafman, in press). Publisher Copyright: © 2012, Springer Science+Business Media, LLC.

PY - 2014/8/1

Y1 - 2014/8/1

N2 - Recovery after Traumatic Brain Injury (TBI) is variable, even for patients with similar severity of brain injury. Recent research has highlighted the contribution that genetic predisposition plays in determining TBI outcome. This review considers the potential for genetic polymorphisms to influence recovery of cognitive and social processes following TBI. Limitations and considerations that researchers should make when assessing the potential impact of polymorphisms on TBI outcome are also discussed. Understanding the genetic factors that support neuroplasticity will contribute to an understanding of the variation in outcome following injury and help to identify potential targets for rehabilitation.

AB - Recovery after Traumatic Brain Injury (TBI) is variable, even for patients with similar severity of brain injury. Recent research has highlighted the contribution that genetic predisposition plays in determining TBI outcome. This review considers the potential for genetic polymorphisms to influence recovery of cognitive and social processes following TBI. Limitations and considerations that researchers should make when assessing the potential impact of polymorphisms on TBI outcome are also discussed. Understanding the genetic factors that support neuroplasticity will contribute to an understanding of the variation in outcome following injury and help to identify potential targets for rehabilitation.

KW - Genetic polymorphisms

KW - Polymorphisms

KW - Traumatic brain injury

UR - http://www.scopus.com/inward/record.url?scp=84907678795&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84907678795&partnerID=8YFLogxK

U2 - 10.1007/s11682-012-9197-9

DO - 10.1007/s11682-012-9197-9

M3 - Article

C2 - 22878895

AN - SCOPUS:84907678795

SN - 1931-7557

VL - 8

SP - 420

EP - 434

JO - Brain Imaging and Behavior

JF - Brain Imaging and Behavior

IS - 3

ER -

Genetic polymorphisms and traumatic brain injury: the contribution of individual differences to recovery

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this