Genetic polymorphisms influence recovery from traumatic brain injury

Starla M. Weaver*, Aileen Chau, Jaclyn N. Portelli, Jordan Grafman

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

Traumatic brain injury (TBI) is a major public health concern in both civilian and military populations. Recently, genetics studies have begun to identify individual differences in polymorphisms that could affect recovery and outcome of cognitive and social processes following TBI. This review considers the potential for polymorphisms to influence six specific cognitive and social functions, which represent the most prominent domains of impairment following TBI: working memory, executive function, decision making, inhibition and impulsivity, aggression, and social and emotional function. Examining the influence of polymorphisms on TBI outcome has the potential to contribute to an understanding of variations in TBI outcome, aid in the triaging and treatment of TBI patients, and ultimately lead to targeted interventions based on genetic profiles.

Original languageEnglish (US)
Pages (from-to)631-644
Number of pages14
JournalNeuroscientist
Volume18
Issue number6
DOIs
StatePublished - Dec 1 2012

Keywords

  • cognition
  • genetics
  • polymorphisms
  • social cognition
  • traumatic brain injury

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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