Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene variant

Cheryl Winkler, William Modi, Michael W. Smith, George W. Nelson, Xueyun Wu, Mary Carrington, Michael Dean, Tasaku Honjo, Kai Tashiro, D. Yabe, Susan Buchbinder, Eric Vittinghoff, James J. Goedert, Thomas R. O'Brien, Lisa P. Jacobson, Roger Detels, Sharyne Donfield, Anne Willoughby, Edward Gomperts, David VlahovJohn Phair, Stephen J. O'Brien*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

634 Scopus citations

Abstract

Stromal-derived factor (SDF-1) is the principal ligand for CXCR4, a coreceptor with CD4 fort lymphocyte cell line-tropic human immunodeficiency virus-type 1 (HIV-1). A common polymorphism, SDF1-3'A, was identified in an evolutionarily conserved segment of the 3' untranslated region of the SDF-1 structural gene transcript. In the homozygous state, SDF1-3'A/3'A delays the onset of acquired immunodeficiency syndrome (AIDS), according to a genetic association analysis of 2857 patients enrolled in five AIDS cohort studies. The recessive protective effect of SDF1-3'A was increasingly pronounced in individuals infected with HIV-1 for longer periods, was twice as strong as the dominant genetic restriction of AIDS conferred by CCR5 and CCR2 chemokine receptor variants in these populations, and was complementary with these mutations in delaying the onset of AIDS.

Original languageEnglish (US)
Pages (from-to)389-393
Number of pages5
JournalScience
Volume279
Issue number5349
DOIs
StatePublished - Jan 16 1998

ASJC Scopus subject areas

  • General

Fingerprint

Dive into the research topics of 'Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene variant'. Together they form a unique fingerprint.

Cite this