Genetic study of indirect inguinal hernia

Yaoqin Gong*, Changshun Shao, Qian Sun, Binxi Chen, Yuan Jiang, Chenhong Guo, Jianjun Wei, Yishou Guo

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

We performed a genetic analysis of 280 families with congenital indirect inguinal hernia ascertained in Shandong province. The multifactorial threshold model and segregation analysis were applied to these families to investigate the mode of inheritance of congenital indirect inguinal hernia. Our results indicate that congenital indirect inguinal hernia is not compatible with a multifactorial threshold model, and the frequent vertical transmission and high segregation ratio suggest autosomal dominant inheritance with incomplete penetrance and sex influence. Through further pedigree analysis of the multiple case families with at least two closely related affected members, we noted preferential paternal transmission of the disease gene, which might suggest the role of genomic imprinting in the aetiology of this condition.

Original languageEnglish (US)
Pages (from-to)187-192
Number of pages6
JournalJournal of medical genetics
Volume31
Issue number3
DOIs
StatePublished - Mar 1994

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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